An author might select the Variation Morality" as the thematic focus, making the thematic conflict Morality vs. Self-Interest. But which is better between the two? It depends on the context. The author's message might be to speak out in favor of putting others first, or that one must first take care of oneself before one can help others. Either point of view is arguable, as long as the argument is complete and makes sense in context.

Because it is simply the point of focus, one might argue for an Issue of Morality by either showing that Morality is a good thing or that Self-interest is bad. Of course, both Variations will take their turn at the forefront in exploring the pair, yet one will be the pivot point around which the throughline revolves. Is the throughline's message about Morality or about Self-Interest? The answer to that question determines the thematic Issue.