Let's assume you have not yet selected any other story points. Begin by picking the throughline you want to work with, that is, Overall Story or Main Character, for example. Don't consider to what Class that throughline is attached. Then, keeping that throughline in your mind, get a feel for the Variations in each Class by simply letting your eyes wander over each set of sixteen and treating them as a single item. Eventually one set should emerge as having the best overall feel for that throughline. In other words, the Variations in that set best express the kinds of thematic issues you will want to explore in that throughline.

Now, think of the sixteen Variations in that set as four groups of four. Each group is a quad, and has a unique flavor that defines the four Variations in it as being part of the same family. Consider all four quads in the set, getting a feel for each one. Then zero in on the quad that best typifies the family of subject matter you wish to address in that throughline.

In the quad you have selected there are two different diagonal pairs of Variations. Pick the diagonal pair (dynamic pair) of Variations that illustrates the thematic conflict you wish to explore. Finally, choose one of the two Variations in the pair to be the focus of your theme, and you have your Issue. The other Variation in the pair is your thematic counterpoint.

In this manner, you can begin with a feeling and end up with a specific dramatic choice that will affect not only theme, but character and plot as well.